Phospho-DREAM (S63) Polyclonal Antibody, 100µg, (ATB-P0930)

Description

Background:

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).

Product datasheet:

Overview
Product Description	Phospho-DREAM (S63) Polyclonal Antibody, 100µg, (ATB-P0930)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human DREAM around the phosphorylation site of S63.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Boichuk S, et al. Cancer Res, 2013 Aug 15. PMID 23786773
2. Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling. Fedrizzi L, et al. J Biol Chem, 2008 Oct 10. PMID 18664571
3. DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management? Reisch N, et al. Arthritis Res Ther, 2008. PMID 18507845 Free PMC Article
4. Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin. Yu L, et al. Protein Sci, 2007 Nov. PMID 17962406 Free PMC Article
5. Expression of calsenilin in neurons and astrocytes in the Alzheimer’s disease brain. Jin JK, et al. Neuroreport, 2005 Apr 4. PMID 15770150
6. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.
   Buxbaum J.D., Choi E.K., Luo Y., Lilliehook C., Crowley A.C., Merriam D.E., Wasco W.
   Nat. Med. 4:1177-1181(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN PRESENILIN REGULATION.
7. DREAM is a Ca2+-regulated transcriptional repressor.
   Carrion A.M., Link W.A., Ledo F., Mellstrom B., Naranjo J.R.
   Nature 398:80-84(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN TRANSCRIPTION REGULATION. Tissue: Caudate nucleus.
8. Modulation of A-type potassium channels by a family of calcium sensors.
   An W.F., Bowlby M.R., Betty M., Cao J., Ling H.-P., Mendoza G., Hinson J.W., Mattsson K.I., Strassle B.W., Trimmer J.S., Rhodes K.J.
   Nature 403:553-556(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION IN POTASSIUM TRANSPORT.
9. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.
   Pruunsild P., Timmusk T.
   Genomics 86:581-593(2005) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING.
10. Isbrandt D., Pongs O.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).