Acetyl-p57 (K278) Polyclonal Antibody, 100ug, (ATB-K0044)

Description

Background:

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Product datasheet:

Overview
Product Description	Acetyl-p57 (K278) Polyclonal Antibody, 100ug, (ATB-K0044)
Image
Species Reactivities	Human, Mouse, Rat
Immunogen	Synthesized peptide derived from human p57 around the acetylation site of K278.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Isotype	IGg

References:

1. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes. Kerns SL, et al. J Clin Endocrinol Metab, 2014 Oct. PMID 25057881
2. IMAGe Syndrome Bennett J, et al. , 1993. PMID 24624461
3. Utility of fluorescence in situ hybridization for ploidy and p57 immunostaining in discriminating hydatidiform moles. Chen KH, et al. Biochem Biophys Res Commun, 2014 Apr 4. PMID 24613849
4. Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome. Hamajima N, et al. PLoS One, 2013. PMID 24098681 Free PMC Article
5. CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell Silver syndrome. Brioude F, et al. J Med Genet, 2013 Dec. PMID 24065356
6. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
   Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J.
   Genes Dev. 9:650-662(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Embryo.
7. Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms’ tumor assay.
   Reid L.H., Crider-Miller S.J., West A., Lee M.H., Massague J., Weissman B.E.
   Cancer Res. 56:1214-1218(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). Tissue: Placenta.
9. Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis.
   Tokino T., Urano T., Furuhata T., Matsushima M., Miyatsu T., Sasaki S., Nakamura Y.
   Hum. Genet. 97:625-631(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-316, VARIANTS.
10. Analysis of germline CDKN1C (p57-KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation.
    Lam W.W.K., Hatada I., Ohishi S., Mukai T., Joyce J.A., Cole T.R.P., Donnai D., Reik W., Schofield P.N., Maher E.R.
    J. Med. Genet. 36:518-523(1999) [PubMed] [Europe PMC] Cited for: INVOLVEMENT IN BWS.