Acetyl-p73 (K327) Polyclonal Antibody, 100ug, (ATB-K0038)

Description

Background:

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Product datasheet:

Overview
Product Description	Acetyl-p73 (K327) Polyclonal Antibody, 100ug, (ATB-K0038)
Image
Species Reactivities	Human, Mouse, Rat
Immunogen	Synthesized peptide derived from the human p73 around the acetylation site of K327.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Isotype	IGg

References:

1. Structural dissection of the C-terminal sterile alpha motif (SAM) of human p73. Neira JL. Arch Biochem Biophys, 2014 Sep 15. PMID 25034213
2. Association of p73 G4C14-to-A4T14 polymorphism with lung cancer risk. Liu H, et al. Tumour Biol, 2014 Sep. PMID 24943681
3. Association between the p73 G4C14-to-A4T14 polymorphism and risk of nasopharyngeal carcinoma: a case-control and family-based study. Zhang X, et al. Carcinogenesis, 2014 Sep. PMID 24590897
4. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Hettmer S, et al. Cancer, 2014 Apr 1. PMID 24382691
5. p73 regulates serine biosynthesis in cancer. Amelio I, et al. Oncogene, 2014 Oct 16. PMID 24186203
6. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.
   Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J.-C., Valent A., Minty A., Chalon P., Lelias J.-M., Dumont X., Ferrara P., McKeon F., Caput D.
   Cell 90:809-819(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). Tissue: Colon.
7. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.
   Mai M., Huang H., Reed C., Qian C., Smith J.S., Alderete B., Jenkins R., Smith D.I., Liu W.
   Genomics 51:359-363(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA).
8. Two new p73 splice variants, gamma and delta, with different transcriptional activity.
   De Laurenzi V., Costanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G.
   J. Exp. Med. 188:1763-1768(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS GAMMA AND DELTA). Tissue: Neuroblastoma.
9. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta.
   De Laurenzi V., Catani M.V., Terrinoni A., Corazzari M., Melino G., Costanzo A., Levrero M., Knight R.A.
   Cell Death Differ. 6:389-390(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EPSILON AND ZETA). Tissue: Hepatoma, Lymphocyte, Mammary cancer and Skin.
10. Mutational analysis of p73 and p53 in human cancer cell lines.
    Yoshikawa H., Nagashima M., Khan M.A., McMenamin M.G., Hagiwara K., Harris C.C.
    Oncogene 18:3415-3421(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA).