Phospho-4.1R (Y660) Polyclonal Antibody, 100µg, (ATB-P0468)

Description

Background:

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.

Product datasheet:

Overview
Product Description	Phospho-4.1R (Y660) Polyclonal Antibody, 100µg, (ATB-P0468)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human 4.1R around the phosphorylation site of Y660.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Structural stabilization of protein 4.1R FERM domain upon binding to apo-calmodulin: novel insights into the biological significance of the calcium-independent binding of calmodulin to protein 4.1R. Nunomura W, et al. Biochem J, 2011 Dec 15. PMID 21848512
2. Nonsense-mediated mRNA decay (NMD) blockage promotes nonsense mRNA stabilization in protein 4.1R deficient cells carrying the 4.1R Coimbra variant of hereditary elliptocytosis. Morinière M, et al. Blood Cells Mol Dis, 2010 Dec 15. PMID 20863723
3. Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population. Xue F, et al. Arch Oral Biol, 2010 Nov. PMID 20797695
4. [Expression and significance of membrane skeleton protein 4.1 family in non-small cell lung cancer]. Zheng XY, et al. Ai Zheng, 2009 Jul. PMID 19624891
5. Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain. Kusunoki H, et al. Proteins, 2009 Jul. PMID 19338061
6. Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.
   Conboy J.G., Kan Y.W., Shohet S.B., Mohandas N.
   Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), PROTEIN SEQUENCE OF 378-393. Tissue: Reticulocyte.
7. Expression of specific isoforms of protein 4.1 in erythroid and non-erythroid tissues.
   Tang T.K., Leto T.L., Marchesi V.T., Benz E.J. Jr.
   Adv. Exp. Med. Biol. 241:81-95(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
8. Selective expression of an erythroid-specific isoform of protein 4.1.
   Tang T.K., Leto T.L., Correas I., Alonso M.A., Marchesi V.T., Benz E.J. Jr.
   Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
9. Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1.
   Conboy J.G., Chan J.Y.C., Chasis J.A., Kan Y.W., Mohandas N.
   J. Biol. Chem. 266:8273-8280(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
10. Sequence of protein 4.1 from a human neuroblastoma cell line: LAN5.
    Huang S.C., Wang C., Lichtenauer U., Vortmeyer A., Zhuang Z.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).