Phospho-Actin-α/γ (Y55/53) Polyclonal Antibody, 100µg, (ATB-P0977)

Description

Background:

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

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References:

1. Exome sequencing identifies a novel variant in ACTC1 associated with familial atrial septal defect. Greenway SC, et al. Can J Cardiol, 2014 Feb. PMID 24461919
2. Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy. Frade AF, et al. PLoS One, 2013. PMID 24367596 Free PMC Article
3. Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy. Müller M, et al. Cell Mol Life Sci, 2012 Oct. PMID 22643837
4. Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. Debold EP, et al. J Mol Cell Cardiol, 2010 Feb. PMID 19799913 Free PMC Article
5. Expression of cardiac alpha-actin spares extraocular muscles in skeletal muscle alpha-actin diseases–quantification of striated alpha-actins by MRM-mass spectrometry. Ravenscroft G, et al. Neuromuscul Disord, 2008 Dec. PMID 18952430
6. Molecular structure and evolutionary origin of human cardiac muscle actin gene.
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   Proc. Natl. Acad. Sci. U.S.A. 79:5901-5905(1982) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
9. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
   Li M.M., Nilsen A., Shi Y., Fusser M., Ding Y.H., Fu Y., Liu B., Niu Y., Wu Y.S., Huang C.M., Olofsson M., Jin K.X., Lv Y., Xu X.Z., He C., Dong M.Q., Rendtlew Danielsen J.M., Klungland A., Yang Y.G.
   Nat. Commun. 4:1832-1832(2013) [PubMed] [Europe PMC] Cited for: METHYLATION AT LYS-86, DEMETHYLATION BY ALKBH4.
10. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure.
    Olson T.M., Michels V.V., Thibodeau S.N., Tai Y.-S., Keating M.T.
    Science 280:750-752(1998) [PubMed] [Europe PMC] Cited for: VARIANTS CMD1R HIS-314 AND GLY-363.