Phospho-Amyloid-β (T743) Polyclonal Antibody, 100 µg, (ATB-P0855)

Description

Background:

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu²⁺-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu²⁺ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

Product datasheet:

References:

1. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor.
   Kang J., Lemaire H.-G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.-H., Multhaup G., Beyreuther K., Mueller-Hill B.
   Nature 325:733-736(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695). Tissue: Brain.
2. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
   Ponte P., Gonzalez-Dewhitt P., Schilling J., Miller J., Hsu D., Greenberg B., Davis K., Wallace W., Lieberburg I., Fuller F., Cordell B.
   Nature 331:525-527(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP751). Tissue: Brain.
3. The PreA4(695) precursor protein of Alzheimer’s disease A4 amyloid is encoded by 16 exons.
   Lemaire H.-G., Salbaum J.M., Multhaup G., Kang J., Bayney R.M., Unterbeck A., Beyreuther K., Mueller-Hill B.
   Nucleic Acids Res. 17:517-522(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP695).
4. Genomic organization of the human amyloid beta-protein precursor gene.
   Yoshikai S., Sasaki H., Doh-ura K., Furuya H., Sakaki Y.
   Gene 87:257-263(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770).
5. Erratum
   Yoshikai S., Sasaki H., Doh-ura K., Furuya H., Sakaki Y.
   Gene 102:291-292(1991) [PubMed] [Europe PMC]
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   J. Biol. Chem. 267:10804-10809(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L-APP733). Tissue: Leukocyte.
7. A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.
   Hattori M., Tsukahara F., Furuhata Y., Tanahashi H., Hirose M., Saito M., Tsukuni S., Sakaki Y.
   Nucleic Acids Res. 25:1802-1808(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770).
8. Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.
   Tang K., Wang C., Shen C., Sheng S., Ravid R., Jing N.
   Eur. J. Neurosci. 18:102-108(2003) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP639), TISSUE SPECIFICITY. Tissue: Brain.
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS APP770 AND 11). Tissue: Cerebellum and Hippocampus.

10. NIEHS SNPs program
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-501.