Phospho-AP-1 (T231) Polyclonal Antibody, 100µg, (ATB-P1139)

Description

Background:

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Transcription factor that recognizes and binds to the enhancer heptamer motif 5′-TGA[CG]TCA-3′. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Product datasheet:

References:

1. Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer. Zhao C, et al. Cancer Res, 2014 Jul 15. PMID 24830720
2. Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma. Luo A, et al. PLoS One, 2014. PMID 24796531 Free PMC Article
3. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Beste MT, et al. Sci Transl Med, 2014 Feb 5. PMID 24500404 Free PMC Article
4. Anticancer activity of Phyllanthus emblica Linn. (Indian gooseberry): inhibition of transcription factor AP-1 and HPV gene expression in cervical cancer cells. Mahata S, et al. Nutr Cancer, 2013. PMID 23682787
5. Proteomic analysis reveals that pardaxin triggers apoptotic signaling pathways in human cervical carcinoma HeLa cells: cross talk among the UPR, c-Jun and ROS. Huang TC, et al. Carcinogenesis, 2013 Aug. PMID 23615400
6. Structure and chromosomal localization of the functional intronless human JUN protooncogene.
   Hattori K., Angel P., le Beau M.M., Karin M.
   Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
   Bohmann D., Bos T.J., Admon A., Nishimura T., Vogt P.K., Tjian R.
   Science 238:1386-1392(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
8. Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
9. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
10. NIEHS SNPs program
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].