Phospho-c-Fos (S32) Polyclonal Antibody, 100µg, (ATB-P0442)

Description

Background:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Product datasheet:

Overview
Product Description	Phospho-c-Fos (S32) Polyclonal Antibody, 100µg, (ATB-P0442)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human c-Fos around the phosphorylation site of S32.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. c-Fos: an AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity. Caputto BL, et al. Biochim Biophys Acta, 2014 Sep. PMID 24886961
2. c-FOS suppresses ovarian cancer progression by changing adhesion. Oliveira-Ferrer L, et al. Br J Cancer, 2014 Feb 4. PMID 24322891 Free PMC Article
3. A mutation in the c-fos gene associated with congenital generalized lipodystrophy. Knebel B, et al. Orphanet J Rare Dis, 2013 Aug 7. PMID 23919306 Free PMC Article
4. [Expression of FOS protein in glioma and its effect on the growth of human glioma cells]. Tao T, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2013 Jun. PMID 23744317
5. Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. Feng X, et al. PLoS One, 2013. PMID 23593403 Free PMC Article
6. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
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7. NIEHS SNPs program
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8. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Colon.

9. The DNA sequence and analysis of human chromosome 14.
   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
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   Nature 421:601-607(2003) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].