Phospho-Casein Kinase Iα (Y294) Polyclonal Antibody, 100µg, (ATB-P0782)

Description

Background:

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ‘Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.

Product datasheet:

Overview
Product Description	Phospho-Casein Kinase Iα (Y294) Polyclonal Antibody, 100µg, (ATB-P0782)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Casein Kinase Iα around the phosphorylation site of Y294.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Panchenko MP, et al. Am J Pathol, 2010 Sep. PMID 20696773 Free PMC Article
2. Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxide. Bedri S, et al. Arch Biochem Biophys, 2007 Oct 15. PMID 17626781 Free PMC Article
3. [Cloning and expression analysis of lung carcinoma related gene HLCDG1]. Xie HL, et al. Ai Zheng, 2003 Oct. PMID 14558941
4. The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism. Gross SD, et al. J Cell Sci, 1999 Aug. PMID 10413673
5. Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. Veis A, et al. Crit Rev Oral Biol Med, 1997. PMID 9391750
6. Cloning and chromosomal localization of the gene coding for human protein kinase CK1.
   Tapia C., Featherstone T., Gomez C., Taillon-Miller P., Allende C.C., Allende J.E.
   FEBS Lett. 349:307-312(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
7. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.
   Fish K.J., Cegielska A., Getman M.E., Landes G.M., Virshup D.M.
   J. Biol. Chem. 270:14875-14883(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
8. Large-scale cDNA transfection screening for genes related to cancer development and progression.
   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
   , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
   , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.

10. Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).