Phospho-CD22 (Y807) Polyclonal Antibody, 100µg, (ATB-P0448)

Description

Background:

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Product datasheet:

Overview
Product Description	Phospho-CD22 (Y807) Polyclonal Antibody, 100µg, (ATB-P0448)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human CD22 around the phosphorylation site of Y807.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. CD22 and autoimmune disease. Dörner T, et al. Int Rev Immunol, 2012 Oct. PMID 23083346
2. CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy. Tuscano JM, et al. Cancer Res, 2012 Nov 1. PMID 22986740
3. Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Kreitman RJ, et al. J Clin Oncol, 2012 May 20. PMID 22355053 Free PMC Article
4. CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia. Ma H, et al. Br J Haematol, 2012 Jan. PMID 22017452
5. Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells. Palanca-Wessels MC, et al. Mol Ther, 2011 Aug. PMID 21629223 Free PMC Article
6. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.
   Stamenkovic I., Seed B.
   Nature 345:74-77(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA).
7. cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions.
   Wilson G.L., Fox C.H., Fauci A.S., Kehrl J.H.
   J. Exp. Med. 173:137-146(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA), VARIANT HIS-639. Tissue: Tonsil.
8. Genomic structure and chromosomal mapping of the human CD22 gene.
   Wilson G.L., Najfeld V., Kozlow E., Menniger J., Ward D., Kehrl J.H.
   J. Immunol. 150:5013-5024(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CD22-ALPHA AND CD22-BETA).
9. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Spleen.
10. The DNA sequence and biology of human chromosome 19.
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].