Phospho-CD4 (S433) Polyclonal Antibody, 100µg, (ATB-P1138)

Description

Background:

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Product datasheet:

References:

1. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. Zhen A, et al. J Virol, 2014 Sep 1. PMID 24942581 Free PMC Article
2. Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women. Hirbod T, et al. J Immunol, 2013 Oct 1. PMID 24006463
3. Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases. Tseng WY, et al. PLoS One, 2013. PMID 23700441 Free PMC Article
4. Control of inflammatory heart disease by CD4+ T cells. Barin JG, et al. Ann N Y Acad Sci, 2013 May. PMID 23692566
5. Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia. Shi J, et al. Blood, 2012 Aug 23. PMID 22797698
6. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
   Maddon P.J., Littman D.R., Godfrey M., Maddon D.E., Chess L., Axel R.
   Cell 42:93-104(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
7. Corrected CD4 sequence.
   Littman D.R., Maddon P.J., Axel R.
   Cell 55:541-541(1988) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION TO 26.
8. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
   Ansari-Lari M.A., Muzny D.M., Lu J., Lu F., Lilley C.E., Spanos S., Malley T., Gibbs R.A.
   Genome Res. 6:314-326(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
9. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
   Ansari-Lari M.A., Shen Y., Muzny D.M., Lee W., Gibbs R.A.
   Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
10. Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.
    Hodge T.W., Sasso D.R., McDougal J.S.
    Hum. Immunol. 30:99-104(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POLYMORPHISM, VARIANT TRP-265.