Phospho-CD50 (S518) Polyclonal Antibody, 100µg, (ATB-P0350)

Description

Background:

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.

Product datasheet:

Overview
Product Description	Phospho-CD50 (S518) Polyclonal Antibody, 100µg, (ATB-P0350)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human CD50 around the phosphorylation site of S518.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. ICAM-3 endows anticancer drug resistance against microtubule-damaging agents via activation of the ICAM-3-AKT/ERK-CREB-2 pathway and blockage of apoptosis. Ahn KC, et al. Biochem Biophys Res Commun, 2013 Nov 15. PMID 24177012
2. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. Kristóf E, et al. Apoptosis, 2013 Oct. PMID 23775590
3. Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3. Appleby SL, et al. PLoS One, 2012. PMID 23144795 Free PMC Article
4. Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. Khoo US, et al. Hong Kong Med J, 2009 Oct. PMID 19801714
5. Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece. Tang XY, et al. J Immunol, 2008 Apr 1. PMID 18354203
6. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.
   Fawcett J., Holness C.L., Needham L.A., Turley H., Gatter K.C., Mason D.Y., Simmons D.L.
   Nature 360:481-484(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS AND GLY-115 GLY-143.
7. Cloning and characterization of a new intercellular adhesion molecule ICAM-R.
   Vazeux R., Hoffman P.A., Tomita J.K., Dickinson E.S., Jasman R.L., St John T., Gallatin W.M.
   Nature 360:485-488(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-115 AND GLY-143.
8. Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.
   de Fougerolles A.R., Kilckstein L.B., Springer T.A.
   J. Exp. Med. 177:1187-1192(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-115 AND GLY-143.
9. Genetic variation in immune response genes.
   Tan J., Ong R., Hibberd M.L., Seielstad M.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
10. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].