Phospho-Cdc25C (S216) Polyclonal Antibody, 100 µg, (ATB-P0058)

Description

Background:

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Product datasheet:

References:

1. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.
   Sadhu K., Reed B.I., Richardson H., Russell P.
   Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-70.
2. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.
   Bureik M., Rief N., Drescher R., Jungbluth A., Montenarh M., Wagner P.
   Int. J. Oncol. 17:1251-1258(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
3. NIEHS SNPs program
   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
4. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-70. Tissue: Skin.
6. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.
   Wegener S., Hampe W., Herrmann D., Schaller H.C.
   Eur. J. Cell Biol. 79:810-815(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-210 (ISOFORMS 2; 4 AND 5), VARIANT CYS-70.
7. Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma.
   Hernandez S., Bessa X., Bea S., Hernandez L., Nadal A., Mallofre C., Muntane J., Castells A., Fernandez P.L., Cardesa A., Campo E.
   Lab. Invest. 81:465-473(2001) [PubMed] [Europe PMC] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Colon carcinoma.
8. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
   Strausfeld U., Fernandez A., Capony J.P., Girard F., Lautredou N., Derancourt J., Labbe J.C., Lamb N.J.
   J. Biol. Chem. 269:5989-6000(1994) [PubMed] [Europe PMC] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-48; THR-67; SER-122; THR-130; SER-168 AND SER-214.
9. The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.
   Ouyang B., Li W., Pan H., Meadows J., Hoffmann I., Dai W.
   Oncogene 18:6029-6036(1999) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION BY PLK3.
10. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase.
    Roshak A.K., Capper E.A., Imburgia C., Fornwald J., Scott G., Marshall L.A.
    Cell. Signal. 12:405-411(2000) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION BY PLK1.