Phospho-CREB-1 (S133) Polyclonal Antibody, 100µg, (ATB-P0075)

Description

Background:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Product datasheet:

Overview
Product Description	Phospho-CREB-1 (S133) Polyclonal Antibody, 100µg, (ATB-P0075)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human CREB-1 around the phosphorylation site of S133.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Manipulating a “cocaine engram” in mice. Hsiang HL, et al. J Neurosci, 2014 Oct 15. PMID 25319707
2. Association of CREB1 gene polymorphism with drug seeking behaviour in eastern Indian addicts. Pal A, et al. Neurosci Lett, 2014 Jun 6. PMID 24704376
3. Inhibition of human cytomegalovirus replication by overexpression of CREB1. Chia YL, et al. Antiviral Res, 2014 Feb. PMID 24316029
4. Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression. Crean D, et al. Exp Cell Res, 2013 Dec 10. PMID 23896026
5. Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression. Guo J, et al. Int J Neurosci, 2014 Jan. PMID 23844928
6. Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
   Berkowitz L.A., Gilman M.Z.
   Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
7. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.
   Yoshimura T., Fujisawa J., Yoshida M.
   EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
8. Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing.
   Waeber G., Meyer T.E., Hoeffler J.P., Habener J.F.
   Trans. Assoc. Am. Physicians 103:28-37(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-A).
9. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.
   Hoeffler J.P., Meyer T.E., Yun Y., Jameson J.L., Habener J.F.
   Science 242:1430-1433(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B).
10. Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells.
    Short M.L., Manohar C.F., Furtado M.R., Ghadge G.D., Wolinsky S.M., Thimmapaya B., Jungmann R.A.
    Nucleic Acids Res. 19:4290-4290(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CREB-B).