Phospho-Dynamin I (S774) Polyclonal Antibody, 100µg, (ATB-P0627)

Description

Background:

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3′ region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Product datasheet:

Overview
Product Description	Phospho-Dynamin I (S774) Polyclonal Antibody, 100µg, (ATB-P0627)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Dynamin I around the phosphorylation site of S774.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. EuroEPINOMICS-RES Consortium, et al. Am J Hum Genet, 2014 Oct 2. PMID 25262651
2. Dynamin protein in stroke and vascular dementia. Mulugeta E, et al. Neurosci Lett, 2014 Mar 20. PMID 24486840
3. Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission. Mehrotra N, et al. Mol Biol Cell, 2014 Mar. PMID 24478459 Free PMC Article
4. Mechanistic insights into mutually exclusive splicing in dynamin 1. Suyama M. Bioinformatics, 2013 Sep 1. PMID 23793749
5. Membrane interaction of disease-related dynorphin A variants. Björnerås J, et al. Biochemistry, 2013 Jun 18. PMID 23705820
6. Mutations in human dynamin block an intermediate stage in coated vesicle formation.
   van der Bliek A.M., Redelmeier T.E., Tisdale E.J., Meyerowitz E.M., Schmid S.L.
   J. Cell Biol. 122:553-563(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 387-466 (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 726-856 (ISOFORM 3), MUTAGENESIS OF LYS-44, VARIANT ASN-744.
7. DNA sequence and analysis of human chromosome 9.
   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
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   Nature 429:369-374(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain and PNS.
9. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
   Soulet F., Yarar D., Leonard M., Schmid S.L.
   Mol. Biol. Cell 16:2058-2067(2005) [PubMed] [Europe PMC] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SNX9.
10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.