Phospho-Eg5 (T926) Polyclonal Antibody, 100µg, (ATB-P0372)

Description

Background:

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

Product datasheet:

Overview
Product Description	Phospho-Eg5 (T926) Polyclonal Antibody, 100µg, (ATB-P0372)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human Eg5 around the phosphorylation site of T926.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Kinetochore-microtubule stability governs the metaphase requirement for Eg5. Gayek AS, et al. Mol Biol Cell, 2014 Jul 1. PMID 24807901 Free PMC Article
2. Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation. Sun L, et al. Biochem Biophys Res Commun, 2014 May 9. PMID 24732354
3. Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations. Jones GE, et al. Eur J Hum Genet, 2014 Jul. PMID 24281367 Free PMC Article
4. Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study. Muretta JM, et al. J Biol Chem, 2013 Nov 29. PMID 24145034 Free PMC Article
5. Adenosine triphosphate hydrolysis mechanism in kinesin studied by combined quantum-mechanical/molecular-mechanical metadynamics simulations. McGrath MJ, et al. J Am Chem Soc, 2013 Jun 19. PMID 23751065
6. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
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   Nature 429:375-381(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
10. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
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