Phospho-eIF4G (S1148) Polyclonal Antibody, 100µg, (ATB-P0970)

Description

Background:

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5′-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5′-terminal secondary structure and recruitment of mRNA to the ribosome.

Product datasheet:

References:

1. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Akabayov SR, et al. Biochemistry, 2014 Oct 21. PMID 25255371
2. EIF4G1 gene mutations are not a common cause of Parkinson’s disease in the Japanese population. Nishioka K, et al. Parkinsonism Relat Disord, 2014 Jun. PMID 24704100
3. EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson’s disease from South Africa. Blanckenberg J, et al. Neurobiol Aging, 2014 Feb. PMID 24080171
4. Analysis of EIF4G1 in ethnic Chinese. Li K, et al. BMC Neurol, 2013 Apr 26. PMID 23617574 Free PMC Article
5. EIF4G1 Ala502Val and Arg1205His variants in Chinese patients with Parkinson disease. Yuan L, et al. Neurosci Lett, 2013 May 24. PMID 23562511
6. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma.
   Yan R., Rychlik W., Etchison D., Rhoads R.E.
   J. Biol. Chem. 267:23226-23231(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), VARIANT VAL-432. Tissue: Brain.
7. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.
   Imataka H., Gradi A., Sonenberg N.
   EMBO J. 17:7480-7489(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), INTERACTION WITH PABPC1.
8. A novel functional human eukaryotic translation initiation factor 4G.
   Gradi A., Imataka H., Svitkin Y.V., Rom E., Raught B., Morino S., Sonenberg N.
   Mol. Cell. Biol. 18:334-342(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
9. Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons.
   Byrd M.P., Zamora M., Lloyd R.E.
   Mol. Cell. Biol. 22:4499-4511(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), VARIANTS ALA-161 AND VAL-432, ALTERNATIVE INITIATION.
10. Complete sequencing and characterization of 21,243 full-length human cDNAs.
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
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    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).