Phospho-FADD (S194) Polyclonal Antibody, 100µg, (ATB-P0628)

Description

Background:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Product datasheet:

Overview
Product Description	Phospho-FADD (S194) Polyclonal Antibody, 100µg, (ATB-P0628)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human FADD around the phosphorylation site of S194.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Fatty acid synthase-associated protein with death domain: a prognostic factor for survival in patients with nasopharyngeal carcinoma. Li J, et al. Hum Pathol, 2014 Dec. PMID 25305096
2. Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast. Choi EJ, et al. World J Surg Oncol, 2014 May 1. PMID 24886289 Free PMC Article
3. Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs. Wang X, et al. Mol Cell Biochem, 2014 Aug. PMID 24752353
4. FADD is upregulated in relapsing remitting multiple sclerosis. Reuss R, et al. Neuroimmunomodulation, 2014. PMID 24603611
5. FADD expression is associated with regional and distant metastasis in squamous cell carcinoma of the head and neck. Pattje WJ, et al. Histopathology, 2013 Aug. PMID 23763459
6. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
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   Cell 81:505-512(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS. Tissue: Umbilical vein endothelial cell.
7. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain.
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   J. Biol. Chem. 270:7795-7798(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
8. Identification of a human growth inhibition gene 3 (GIG3).
   Kim J.W.
   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

10. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].