Phospho-GFAP (S38) Polyclonal Antibody, 100µg, (ATB-P0948)

Description

Background:

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Product datasheet:

Overview
Product Description	Phospho-GFAP (S38) Polyclonal Antibody, 100µg, (ATB-P0948)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human GFAP around the phosphorylation site of S38.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Enteric GFAP expression and phosphorylation in Parkinson’s disease. Clairembault T, et al. J Neurochem, 2014 Sep. PMID 24749759
2. Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products. Zhang Z, et al. PLoS One, 2014. PMID 24667434 Free PMC Article
3. Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia. Williams M, et al. Eur Arch Psychiatry Clin Neurosci, 2014 Jun. PMID 24374936
4. Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer’s disease. Kamphuis W, et al. Neurobiol Aging, 2014 Mar. PMID 24269023
5. Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation. Chen MH, et al. ASN Neuro, 2013 Nov 19. PMID 24102621 Free PMC Article
6. Molecular cloning and primary structure of human glial fibrillary acidic protein.
   Reeves S.A., Helman L.J., Allison A., Israel M.A.
   Proc. Natl. Acad. Sci. U.S.A. 86:5178-5182(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
7. Characterization of human cDNA and genomic clones for glial fibrillary acidic protein.
   Brenner M., Lampel K., Nakatani Y., Mill J., Banner C., Mearow K., Dohadwala M., Lipsky R., Freese E.
   Brain Res. Mol. Brain Res. 7:277-286(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
8. Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
   Bongcam-Rudloff E., Nister M., Betsholtz C., Wang J.-L., Stenman G., Huebner K., Croce C.M., Westermark B.
   Cancer Res. 51:1553-1560(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
9. Human glial fibrillary acidic protein (GFAP): molecular cloning of the complete cDNA sequence and chromosomal localization (chromosome 17) of the GFAP gene.
   Kumanishi T., Usui H., Ichikawa T., Nishiyama A., Katagiri T., Abe S., Yoshida Y., Washiyama K., Kuwano R., Sakimura K.
   Acta Neuropathol. 83:569-578(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
10. Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17.
    Isaacs A., Baker M., Wavrant-De Vrieze F., Hutton M.
    Genomics 51:152-154(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-295.