Phospho-GSK3α (S21) Polyclonal Antibody, 100µg, (ATB-P0122)

Description

Background:

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer’s disease. [provided by RefSeq, Oct 2011]

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Product datasheet:

Overview
Product Description	Phospho-GSK3α (S21) Polyclonal Antibody, 100µg, (ATB-P0122)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human GSK3α around the phosphorylation site of S21.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

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2. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. Banerji V, et al. J Clin Invest, 2012 Mar. PMID 22326953 Free PMC Article
3. Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages. Larabee JL, et al. Infect Immun, 2011 Aug. PMID 21576335 Free PMC Article
4. Is glycogen synthase kinase-3 a central modulator in mood regulation? Li X, et al. Neuropsychopharmacology, 2010 Oct. PMID 20668436 Free PMC Article
5. Expression and function of glycogen synthase kinase-3 in human hair follicles. Yamauchi K, et al. Arch Dermatol Res, 2010 May. PMID 19705135
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7. Isolation of cDNA clones for human glycogen synthase kinase 3alpha.
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   Nature 428:529-535(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Pancreas.
10. Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
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    Diabetes 49:263-271(2000) [PubMed] [Europe PMC] Cited for: ASSOCIATION WITH DIABETES MELLITUS.