Phospho-HDAC1 (S421) Polyclonal Antibody, 100µg, (ATB-P0337)

Description

Background:

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates ‘Lys-310’ in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

Product datasheet:

Overview
Product Description	Phospho-HDAC1 (S421) Polyclonal Antibody, 100µg, (ATB-P0337)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human HDAC1 around the phosphorylation site of S421.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics. Kim MH, et al. Korean J Intern Med, 2013 Nov. PMID 24307847 Free PMC Article
2. The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in endometriosis. Samartzis EP, et al. Reprod Sci, 2013 Dec. PMID 23690335 Free PMC Article
3. Identification of histone deacetylase 1 protein complexes in liver cancer cells. Farooq M, et al. Asian Pac J Cancer Prev, 2013. PMID 23621261
4. Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. Pelascini LP, et al. Hum Gene Ther, 2013 Jan. PMID 23140481 Free PMC Article
5. Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. Conway GD, et al. Glia, 2012 Dec. PMID 22927334
6. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
   Taunton J., Hassig C.A., Schreiber S.L.
   Science 272:408-411(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
7. Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae.
   Furukawa Y., Kawakami T., Sudo K., Inazawa J., Matsumine A., Akiyama T., Nakamura Y.
   Cytogenet. Cell Genet. 73:130-133(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung.
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
9. MEF-2 function is modified by a novel co-repressor, MITR.
   Sparrow D.B., Miska E.A., Langley E., Reynaud-Deonauth S., Kotecha S., Towers N., Spohr G., Kouzarides T., Mohun T.J.
   EMBO J. 18:5085-5098(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH HDAC9.
10. BCoR, a novel corepressor involved in BCL-6 repression.
    Huynh K.D., Fischle W., Verdin E., Bardwell V.J.
    Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] Cited for: INTERACTION WITH BCOR.