Phospho-HSP27 (S15) Polyclonal Antibody, 100µg, (ATB-P0134)

Description

Background:

The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

Involved in stress resistance and actin organization.

Product datasheet:

Overview
Product Description	Phospho-HSP27 (S15) Polyclonal Antibody, 100µg, (ATB-P0134)
Image
Species Reactivities	Human,Monkey
Immunogen	Synthesized peptide derived from human HSP27 around the phosphorylation site of S15.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme. Belkacemi L, et al. Anticancer Res, 2014 Sep. PMID 25202074
2. Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells. Stope MB, et al. Anticancer Res, 2014 Jul. PMID 24982356
3. Heat shock protein-27 delays acute rejection after cardiac transplantation: an experimental model. Seemampillai B, et al. Transplantation, 2014 Jul 15. PMID 24879379 Free PMC Article
4. Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression. Voll EA, et al. Oncotarget, 2014 May 15. PMID 24798191 Free PMC Article
5. Increased expression of HSP27 inhibits invasion and metastasis in human esophageal squamous cell carcinoma. Xue L, et al. Tumour Biol, 2014 Jul. PMID 24748206
6. Sequence and organization of genes encoding the human 27 kDa heat shock protein.
   Hickey E., Brandon S.E., Potter R., Stein G., Stein J., Weber L.A.
   Nucleic Acids Res. 14:4127-4145(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. cDNA sequence of a human heat shock protein HSP27.
   Carper S.W., Rocheleau T.A., Storm F.K.
   Nucleic Acids Res. 18:6457-6457(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
8. Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.
   Hino M., Kurogi K., Okubo M.-A., Murata-Hori M., Hosoya H.
   Biochem. Biophys. Res. Commun. 271:164-169(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, SUBUNIT. Tissue: Cervix carcinoma.
9. Identification of a new cDNA sequence from human breast carcinoma cells encoding the 28kDa heat shock protein.
   Briolay J., Chareyron P., Mehlen P., Arrigo A.
   Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma.
10. Large-scale concatenation cDNA sequencing.
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.