Phospho-ICAM-1 (Y512) Polyclonal Antibody, 100µg, (ATB-P0137)

Description

Background:

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Product datasheet:

Overview
Product Description	Phospho-ICAM-1 (Y512) Polyclonal Antibody, 100µg, (ATB-P0137)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human ICAM-1 around the phosphorylation site of Y512.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma. Li YF, et al. Int J Environ Res Public Health, 2014 Jun. PMID 25003170 Free PMC Article
2. SAOS-2 osteosarcoma cells bind fibroblasts via ICAM-1 and this is increased by tumour necrosis factor-α. David MS, et al. PLoS One, 2014. PMID 24979620 Free PMC Article
3. Atomic force microscopy reveals a role for endothelial cell ICAM-1 expression in bladder cancer cell adherence. Laurent VM, et al. PLoS One, 2014. PMID 24857933 Free PMC Article
4. Role of ICAM-1 polymorphisms (G241R, K469E) in mediating its single-molecule binding ability: atomic force microscopy measurements on living cells. Bai R, et al. Biochem Biophys Res Commun, 2014 Jun 13. PMID 24792184
5. Impacts of ICAM-1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan. Wang SS, et al. Tumour Biol, 2014 Aug. PMID 24789429
6. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.
   Simmons D., Makgoba M.W., Seed B.
   Nature 331:624-627(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469.
7. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.
   Staunton D.E., Marlin S.D., Stratowa C., Dustin M.L., Springer T.A.
   Cell 52:925-933(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469.
8. cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.
   Tomassini J.E., Graham D., Dewitt C.M., Lineberger D.W., Rodkey J.A., Colonno R.J.
   Proc. Natl. Acad. Sci. U.S.A. 86:4907-4911(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
9. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester.
   Voraberger G.F., Schaefer R., Stratowa C.
   J. Immunol. 147:2777-2786(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-469.
10. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].