Phospho-IGF-IIR (S2409) Polyclonal Antibody, 100µg, (ATB-P0763)

Description

Background:

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Product datasheet:

Overview
Product Description	Phospho-IGF-IIR (S2409) Polyclonal Antibody, 100µg, (ATB-P0763)
Image
Species Reactivities	Human,Mouse,Monkey
Immunogen	Synthesized peptide derived from human IGF-IIR around the phosphorylation site of S2409.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Silencing the mannose 6-phosphate/IGF-II receptor differentially affects tumorigenic properties of normal breast epithelial cells. Caixeiro NJ, et al. Int J Cancer, 2013 Dec 1. PMID 23686499
2. The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells. Probst OC, et al. Biochem J, 2013 Apr 1. PMID 23347038 Free PMC Article
3. Dominant-negative effect of truncated mannose 6-phosphate/insulin-like growth factor II receptor species in cancer. Kreiling JL, et al. FEBS J, 2012 Aug. PMID 22681933 Free PMC Article
4. Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells. Leksa V, et al. J Biol Chem, 2012 Jun 29. PMID 22613725 Free PMC Article
5. Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non-risk allele colorectal cancer associated with insulin growth factor 2 receptor expression. Takahashi Y, et al. J Gastroenterol Hepatol, 2012 Apr. PMID 22486879
6. Insulin-like growth factor II receptor as a multifunctional binding protein.
   Morgan D.O., Edman J.C., Standring D.N., Fried V.A., Smith M.C., Roth R.A., Rutter W.J.
   Nature 329:301-307(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT GLY-1619.
7. The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.
   Oshima A., Nolan C.M., Kyle J.W., Grubb J.H., Sly W.S.
   J. Biol. Chem. 263:2553-2562(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-1619.
8. The genomic structure of the gene encoding the human mannose 6 phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R).
   Gemma A., Seike Y., Uematsu K., Seike M., Bennett W.P., Harris C.C., Kudoh S.
   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-1619.
9. Genomic structure of the human M6P/IGF2 receptor.
   Killian J.K., Jirtle R.L.
   Mamm. Genome 10:74-77(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
10. NIEHS SNPs program
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-91; LEU-203; ASP-231; VAL-252; GLY-273; GLN-512; SER-604; THR-724; VAL-817; SER-856; MET-1107; ILE-1124; SER-1184; GLU-1315; HIS-1335; GLY-1619; HIS-1832; ASP-1860; MET-1908; SER-2020 AND VAL-2459.