Phospho-IL-2Rβ (Y364) Polyclonal Antibody, 100µg, (ATB-P0370)
$238.00
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Description
Background:
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Product datasheet:
Overview | |
| Product Description | Phospho-IL-2Rβ (Y364) Polyclonal Antibody, 100µg, (ATB-P0370) |
| Image | ![]() |
| Species Reactivities | Human,Mouse,Rat,Monkey |
| Immunogen | Synthesized peptide derived from human IL-2Rβ around the phosphorylation site of Y364. |
Properties | |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instructions | -20°C/1 year |
| Clonality | Polyclonal |
References:
- Abnormal expression pattern of the IL-2 receptor β-chain on CD4+ T cells in ANCA-associated vasculitis. Wilde B, et al. Dis Markers, 2014. PMID 24648606 Free PMC Article
- Oxalate upregulates expression of IL-2Rβ and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells. Koul S, et al. Am J Physiol Renal Physiol, 2014 May 1. PMID 24523387
- Neutrality of miniSTR D22S1045 marker by Ewing’s sarcoma phenotype. Silva DS, et al. Leg Med (Tokyo), 2013 Nov. PMID 24112992
- Placenta-specific expression of the interleukin-2 (IL-2) receptor β subunit from an endogenous retroviral promoter. Cohen CJ, et al. J Biol Chem, 2011 Oct 14. PMID 21865161 Free PMC Article
- Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment. Montes de Oca P, et al. J Biol Chem, 2010 Jul 16. PMID 20495002 Free PMC Article
- Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA’s.
Hatakeyama M., Tsudo M., Minamoto S., Kono T., Doi T., Miyata T., Miyasaka M., Taniguchi T.
Science 244:551-556(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. - A genome annotation-driven approach to cloning the human ORFeome.
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. - SeattleSNPs variation discovery resource
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-83 AND GLU-391. - Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
- The DNA sequence of human chromosome 22.
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].


| size | chest(in.) | waist(in.) | hips(in.) |
|---|---|---|---|
| XS | 34-36 | 27-29 | 34.5-36.5 |
| S | 36-38 | 29-31 | 36.5-38.5 |
| M | 38-40 | 31-33 | 38.5-40.5 |
| L | 40-42 | 33-36 | 40.5-43.5 |
| XL | 42-45 | 36-40 | 43.5-47.5 |
| XXL | 45-48 | 40-44 | 47.5-51.5 |





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