Phospho-Integrin β4 (Y1510) Polyclonal Antibody, 100µg, (ATB-P0755)

Description

Background:

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

Product datasheet:

Overview
Product Description	Phospho-Integrin β4 (Y1510) Polyclonal Antibody, 100µg, (ATB-P0755)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Integrin β4 around the phosphorylation site of Y1510.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Circulating tumor cells from 4D model have less integrin beta 4 expression. Mishra DK, et al. J Surg Res, 2015 Feb. PMID 25234746
2. Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4. Yang ZY, et al. Carcinogenesis, 2013 Dec. PMID 23803695
3. ITGB4-associated non-Herlitz junctional epidermolysis bullosa: report of two new cases carrying two novel ITGB4 mutations. Yuen WY, et al. Br J Dermatol, 2013 Feb. PMID 23013259
4. The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of β4 integrin phosphorylation. Kashyap T, et al. J Biol Chem, 2012 Sep 21. PMID 22865863 Free PMC Article
5. Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens. Liu C, et al. PLoS One, 2012. PMID 22545078 Free PMC Article
6. Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.
   Suzuki S., Naitoh Y.
   EMBO J. 9:757-763(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-4A), VARIANT PRO-1779.
7. Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.
   Hogervorst F., Kuikman I., von Dem Borne A.E.G.K., Sonnenberg A.
   EMBO J. 9:765-770(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-4B), VARIANT PRO-1779.
8. Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
   Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V.
   J. Cell Biol. 111:1593-1604(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-4C). Tissue: Pancreas.
9. Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia.
   Pulkkinen L., Kurtz K.S., Xu Y., Bruckner-Tuderman L., Uitto J.
   Lab. Invest. 76:823-833(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BETA-4A; BETA-4B AND BETA-4C), VARIANTS SER-1764 AND PRO-1779.
10. Genomic organization of the human integrin beta 4 gene.
    Iacovacci S., Gagnoux-Palacios L., Zambruno G., Meneguzzi G., D’Alessio M.
    Mamm. Genome 8:448-450(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS BETA-4A; BETA-4B AND BETA-4C), VARIANTS SER-1764 AND PRO-1779. Tissue: Lung.