Phospho-Intestinal Cell Kinase (Y159) Polyclonal Antibody, 100µg, (ATB-P0421)

Description

Background:

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).

Product datasheet:

Overview
Product Description	Phospho-Intestinal Cell Kinase (Y159) Polyclonal Antibody, 100µg, (ATB-P0421)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Intestinal Cell Kinase around the phosphorylation site of Y159.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells. Fu Z, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Oct. PMID 19696144 Free PMC Article
2. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. Lahiry P, et al. Am J Hum Genet, 2009 Feb. PMID 19185282 Free PMC Article
3. Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. Fu Z, et al. Mol Cell Biol, 2005 Jul. PMID 15988018 Free PMC Article
4. The identification and subcellular localization of human MRK. Yang T, et al. Biomol Eng, 2002 Jun. PMID 12103360
5. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. Togawa K, et al. J Cell Physiol, 2000 Apr. PMID 10699974
6. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases.
   Togawa K., Yan Y.-X., Inomoto T., Slaugenhaupt S.A., Rustgi A.K.
   3.0.CO;2-S”>J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-33; LYS-34; LYS-36; LYS-38; THR-157 AND TYR-159, PHOSPHORYLATION AT THR-157 AND TYR-159. Tissue: Colon1 Publication

7. <p>Manually curated information for which there is published experimental evidence.</p>
10. <p><a href=”/manual/evidences#ECO:0000269″>More…</a></p> Manual assertion based on experiment inⁱ
    Ref.1
    Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases.
    Togawa K., Yan Y.-X., Inomoto T., Slaugenhaupt S.A., Rustgi A.K.
    3.0.CO;2-S”>J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-33; LYS-34; LYS-36; LYS-38; THR-157 AND TYR-159, PHOSPHORYLATION AT THR-157 AND TYR-159.