Phospho-Jun D (S255) Polyclonal Antibody, 100µg, (ATB-P0160)

Description

Background:

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Transcription factor binding AP-1 sites.

Product datasheet:

Overview
Product Description	Phospho-Jun D (S255) Polyclonal Antibody, 100µg, (ATB-P0160)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Jun D around the phosphorylation site of S255.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d’etude des Tumeurs Endocrines (GTE) cohort study. Thevenon J, et al. Hum Mol Genet, 2013 May 15. PMID 23376981
2. Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3′ long terminal repeat. Gazon H, et al. J Virol, 2012 Sep. PMID 22696638 Free PMC Article
3. JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer. Zerbini LF, et al. Cell Cycle, 2011 Aug 1. PMID 21734453 Free PMC Article
4. JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Caffarel MM, et al. Oncogene, 2008 Aug 28. PMID 18454173
5. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. Mehraein-Ghomi F, et al. Prostate, 2008 Jun 15. PMID 18386285
6. Structure and function of human jun-D.
   Berger I., Shaul Y.
   Oncogene 6:561-566(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
7. NIEHS SNPs program
   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-20.
8. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
9. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.
    Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
    Nucleic Acids Res. 18:3047-3048(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-347.