Phospho-KIR5.1 (S416) Polyclonal Antibody, 100µg, (ATB-P0938)

Description

Background:

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity).

Product datasheet:

Overview
Product Description	Phospho-KIR5.1 (S416) Polyclonal Antibody, 100µg, (ATB-P0938)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human KIR5.1 around the phosphorylation site of S416.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome. Paulais M, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21633011 Free PMC Article
2. Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16). Trapp S, et al. Exp Physiol, 2011 Apr. PMID 21239463 Free PMC Article
3. Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity. D’Adamo MC, et al. J Biol Chem, 2011 Jan 7. PMID 21047793 Free PMC Article
4. Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Zaika OL, et al. Am J Physiol Renal Physiol, 2013 Nov 1. PMID 23986512 Free PMC Article
5. Kir4.1/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells. Lachheb S, et al. Am J Physiol Renal Physiol, 2008 Jun. PMID 18367659
6. Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11.
   Mouri T., Kittaka N., Horio Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Kurachi Y.
   Genomics 54:181-182(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
   Tissue: Brain.
7. Interaction of inner ear-specific Kir channels.
   Nie L., Feng W.H., Vazquez A.E., Yamoah E.N.
   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
   Tissue: Cochlea.
8. The transcriptional landscape of the mammalian genome.
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   Science 309:1559-1563(2005) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
   Tissue: Cecum, Corpora quadrigemina and Olfactory bulb.

9. Lineage-specific biology revealed by a finished genome assembly of the mouse.
   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.
   , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
   PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].