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Phospho-KV2.1 (S805) Polyclonal Antibody, 100µg, (ATB-P0472)

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Description

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

Product datasheet:

Overview

Product Description   Phospho-KV2.1 (S805) Polyclonal Antibody, 100µg, (ATB-P0472)
Image
Species ReactivitiesHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from human KV2.1 around the phosphorylation site of S805.

Properties

FormLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions-20°C/1 year
ClonalityPolyclonal

References:

  1. De novo KCNB1 mutations in epileptic encephalopathy. Torkamani A, et al. Ann Neurol, 2014 Oct. PMID 25164438
  2. An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population. Zhang YX, et al. PLoS One, 2013. PMID 23431371 Free PMC Article
  3. Toxic role of K+ channel oxidation in mammalian brain. Cotella D, et al. J Neurosci, 2012 Mar 21. PMID 22442077
  4. Dynamic modulation of the kv2.1 channel by SRC-dependent tyrosine phosphorylation. Song MY, et al. J Proteome Res, 2012 Feb 3. PMID 22106938 Free PMC Article
  5. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. Bocksteins E, et al. Eur Biophys J, 2011 Jun. PMID 21455829
  6. Cloning and characterization of a human delayed rectifier potassium channel gene.
    Albrecht B., Lorra C., Stocker K., Pongs O.
    Recept. Channels 1:99-110(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. Heterologous expression of the human potassium channel Kv2.1 in clonal mammalian cells by direct cytoplasmic microinjection of cRNA.
    Ikeda S.R., Soler F., Zuhlke R.D., Joho R.H., Lewis D.L.
    Pflugers Arch. 422:201-203(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain cortex.
  8. Identification of potassium channels in human lens epithelium.
    Rae J.L., Shepard A.R.
    (In) Civan M.M. (eds.);
  9. The eye’s aqueous humor-from secretion to glaucoma, pp.69-104, Academic Press, San Diego (1998)

Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens epithelium.

  • The DNA sequence and comparative analysis of human chromosome 20.
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    • external
    sizechest(in.)waist(in.)hips(in.)
    XS34-3627-2934.5-36.5
    S36-3829-3136.5-38.5
    M38-4031-3338.5-40.5
    L40-4233-3640.5-43.5
    XL42-4536-4043.5-47.5
    XXL45-4840-4447.5-51.5

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