Phospho-MEF-2D (S444) Polyclonal Antibody, 100µg, (ATB-P0165)

Description

Background:

This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Transcriptional activator which binds specifically to the MEF2 element, 5′-YTA[AT]₄TAR-3′, found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).

Product datasheet:

Overview
Product Description	Phospho-MEF-2D (S444) Polyclonal Antibody, 100µg, (ATB-P0165)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human MEF-2D around the phosphorylation site of S444.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes. Ma L, et al. Cancer Res, 2014 Mar 1. PMID 24390737
2. Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells. Zhang M, et al. Mol Cancer, 2013 Nov 27. PMID 24279793 Free PMC Article
3. [Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic]. Li Y, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2011 Sep. PMID 22256741
4. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Breitbart RE, et al. Development, 1993 Aug. PMID 8269842
5. Oxidation of survival factor MEF2D in neuronal death and Parkinson’s disease. Gao L, et al. Antioxid Redox Signal, 2014 Jun 20. PMID 24219011
6. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.
   Breitbart R.E., Liang C.-S., Smoot L.B., Laheru D.A., Mahdavi V., Nadal-Ginard B.
   Development 118:1095-1106(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS MEF2D00; MEF2D0B; MEF2DA’0; MEF2DA’B; MEF2DA0 AND MEF2DAB). Tissue: Myocardium.
7. The DNA sequence and biological annotation of human chromosome 1.
   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
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   Nature 441:315-321(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS MEF2DA0 AND MEF2DAB). Tissue: Eye and Testis.
10. Regulation of the MEF2 family of transcription factors by p38.
    Zhao M., New L., Kravchenko V.V., Kato Y., Gram H., di Padova F., Olson E.N., Ulevitch R.J., Han J.-D.
    Mol. Cell. Biol. 19:21-30(1999) [PubMed] [Europe PMC] Cited for: HETERODIMERIZATION.