Phospho-MEK Kinase-1 (T1402) Polyclonal Antibody, 100µg, (ATB-P0786)

Description

Background:

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Product datasheet:

Overview
Product Description	Phospho-MEK Kinase-1 (T1402) Polyclonal Antibody, 100µg, (ATB-P0786)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human MEK Kinase-1 around the phosphorylation site of T1402.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Association between mitogen-activated protein kinase kinase kinase 1 polymorphisms and breast cancer susceptibility: a meta-analysis of 20 case-control studies. Zheng Q, et al. PLoS One, 2014. PMID 24595411 Free PMC Article
2. Silencing MAP3K1 expression through RNA interference enhances paclitaxel-induced cell cycle arrest in human breast cancer cells. Hu P, et al. Mol Biol Rep, 2014 Jan. PMID 24253898
3. Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control study. Szczepankiewicz A, et al. J Asthma, 2012 May. PMID 22468730
4. Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1. Tricker E, et al. PLoS One, 2011 Feb 25. PMID 21364884 Free PMC Article
5. Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells. Su F, et al. J Cancer Res Clin Oncol, 2009 Dec. PMID 19513748
6. The DNA sequence and comparative analysis of human chromosome 5.
   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
   , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
   Nature 431:268-274(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

7. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
   Xia Y., Wu Z., Su B., Murray B., Karin M.
   Genes Dev. 12:3369-3381(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-1512, FUNCTION, INTERACTION WITH MAP2K4.
8. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.
   Vinik B.S., Kay E.S., Fiedorek F.T. Jr.
   Mamm. Genome 6:782-783(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1274. Tissue: Leukocyte.
9. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.
   Rui H.L., Fan E., Zhou H.M., Xu Z., Zhang Y., Lin S.C.
   J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] Cited for: INTERACTION WITH AXIN1.
10. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] Cited for: INTERACTION WITH AXIN1.