Phospho-Moesin/Ezrin/Radixin (T558) Polyclonal Antibody, 100µg, (ATB-P0940)

Description

Background:

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Product datasheet:

Overview
Product Description	Phospho-Moesin/Ezrin/Radixin (T558) Polyclonal Antibody, 100µg, (ATB-P0940)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Moesin/Ezrin/Radixin around the phosphorylation site of T558.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Moesin overexpression is a unique biomarker of adenomyosis. Ohara R, et al. Pathol Int, 2014 Mar. PMID 24698421
2. The expression of moesin in astrocytoma: correlation with pathologic grade and poor clinical outcome. Wu M, et al. Med Oncol, 2013 Mar. PMID 23315217
3. Differential expression of moesin in breast cancers and its implication in epithelial-mesenchymal transition. Wang CC, et al. Histopathology, 2012 Jul. PMID 22439598
4. Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker. Ben-Aissa K, et al. J Biol Chem, 2012 May 11. PMID 22433855 Free PMC Article
5. Knockdown of ERM family member moesin in host cells increases HIV type 1 replication. Capalbo G, et al. AIDS Res Hum Retroviruses, 2011 Dec. PMID 21486194
6. Moesin: a member of the protein 4.1-talin-ezrin family of proteins.
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
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10. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.
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    J. Cell Biol. 139:169-179(1997) [PubMed] [Europe PMC] Cited for: INTERACTION WITH SLC9A3R1.