Phospho-Mucin 1 (Y1229) Polyclonal Antibody, 100µg, (ATB-P0946)

Description

Background:

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.

Product datasheet:

Overview
Product Description	Phospho-Mucin 1 (Y1229) Polyclonal Antibody, 100µg, (ATB-P0946)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human Mucin 1 around the phosphorylation site of Y1229.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Quantitative assessment of the diagnostic role of MUC1 in pancreatic ductal adenocarcinoma. Wang S, et al. Tumour Biol, 2014 Sep. PMID 25027396
2. CA15-3 is a useful serum tumor marker for diagnostic integration of hybrid positron emission tomography with integrated computed tomography during follow-up of breast cancer patients. Incoronato M, et al. BMC Cancer, 2014 May 21. PMID 24886519 Free PMC Article
3. Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. Zhang L, et al. J Pathol, 2014 Sep. PMID 24838315 Free PMC Article
4. Aberrant expression of CD227 is correlated with tumor characteristics and invasiveness of breast carcinoma. Wang YW, et al. J Cancer Res Clin Oncol, 2014 Aug. PMID 24788565
5. Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells. Alam M, et al. Oncotarget, 2014 May 15. PMID 24770886 Free PMC Article
6. Cloning and sequencing of a human pancreatic tumor mucin cDNA.
   Lan M.S., Batra S.K., Qi W.-N., Metzgar R.S., Hollingsworth M.A.
   J. Biol. Chem. 265:15294-15299(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pancreatic carcinoma.
7. Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini.
   Ligtenberg M.J.L., Vos H.L., Gennissen A.M.C., Hilkens J.
   J. Biol. Chem. 265:5573-5578(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
8. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.
   Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.-N., Wilson D.
   J. Biol. Chem. 265:15286-15293(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary carcinoma.
9. Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit.
   Lancaster C.A., Peat N., Duhig T., Wilson D., Taylor-Papadimitriou J., Gendler S.J.
   Biochem. Biophys. Res. Commun. 173:1019-1029(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
10. Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms.
    Wreschner D.H., Hareuveni M., Tsarfaty I., Smorodinsky N., Horev J., Zaretsky J., Kotkes P., Weiss M., Lathe R., Dion A., Keydar I.
    Eur. J. Biochem. 189:463-473(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Mammary carcinoma.