Phospho-Na+/K+-ATPase α1 (S23) Polyclonal Antibody, 100µg, (ATB-P0563)

Description

Background:

mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Product datasheet:

Overview
Product Description	Phospho-Na+/K+-ATPase α1 (S23) Polyclonal Antibody, 100µg, (ATB-P0563)
Image
Species Reactivities	Rat
Immunogen	Synthesized peptide derived from human Na+/K+-ATPase α1 around the phosphorylation site of S23.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Liu Y, et al. Proc Natl Acad Sci U S A, 2013 Dec 17. PMID 24277826 Free PMC Article
2. Effects of cobalt on membrane ATPases, oxidant, and antioxidant values in the cerebrum and cerebellum of suckling rats. Garoui E, et al. Biol Trace Elem Res, 2013 Sep. PMID 23857379 Free PMC Article
3. Alteration of aluminium inhibition of synaptosomal (Na(+)/K(+))ATPase by colestipol administration. Silva VS, et al. J Inorg Biochem, 2013 Nov. PMID 23829947
4. Identification of a mutant α1 Na/K-ATPase that pumps but is defective in signal transduction. Lai F, et al. J Biol Chem, 2013 May 10. PMID 23532853 Free PMC Article
5. Ovariectomy causes overexpression of renal Na(+),K(+)-ATPase and sodium-sensitive hypertension in adult Wistar rats. Di Ciano LA, et al. Clin Exp Hypertens, 2013. PMID 23327671
6. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.
   Shull G.E., Greeb J., Lingrel J.B.
   Biochemistry 25:8125-8132(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Kidney.
7. Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences.
   Hara Y., Urayama O., Kawakami K., Nojima H., Nagamune H., Kojima T., Ohta T., Nagano K., Nakao M.
   J. Biochem. 102:43-58(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
8. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.
   Herrera V.L.M., Emanuel J.R., Ruiz-Opazo N., Levenson R., Nadal-Ginard B.
   J. Cell Biol. 105:1855-1865(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
10. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKBCited for: PROTEIN SEQUENCE OF 157-162; 597-605; 630-647; 662-671 AND 744-773, IDENTIFICATION BY MASS SPECTROMETRY. Strain: Sprague-Dawley.
    Tissue: Brain.