Phospho-NF2 (S10) Polyclonal Antibody, 100µg, (ATB-P0772)

Description

Background:

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Product datasheet:

Overview
Product Description	Phospho-NF2 (S10) Polyclonal Antibody, 100µg, (ATB-P0772)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human NF2 around the phosphorylation site of S10.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Molecular insights into NF2/Merlin tumor suppressor function. Cooper J, et al. FEBS Lett, 2014 Aug 19. PMID 24726726
2. The role of NF2 gene mutations and pathogenesis-related proteins in sporadic vestibular schwannomas in young individuals. Chen H, et al. Mol Cell Biochem, 2014 Jul. PMID 24619252
3. In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. Gavilan HS, et al. PLoS One, 2014. PMID 24595234 Free PMC Article
4. A deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma. Zemmoura I, et al. Neuro Oncol, 2014 Jan. PMID 24357459 Free PMC Article
5. Loss of NF2/Merlin expression in advanced sporadic colorectal cancer. Cačev T, et al. Cell Oncol (Dordr), 2014 Feb. PMID 24323642
6. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
   Trofatter J.A., Maccollin M.M., Rutter J.L., Murrell J.R., Duyao M.P., Parry D.N., Eldridge R., Kley N., Menon A.G., Pulaski K., Haase V.H., Ambrose C.M., Munroe D., Bove C., Haines J.L., Martuza R.L., Macdonald M.E., Seizinger B.R.
   , Short M.P., Buckler A.J., Gusella J.F.
   Cell 72:791-800(1993) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).

7. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2.
   Rouleau G.A., Merel P., Lutchman M., Sanson M., Zucman J., Marineau C., Hoang-Xuan K., Demczuk S., Desmaze C., Plougastel B., Pulst S., Lenoir G., Bijlsma E., Fashold R., Dumanski J.P., de Jong P., Parry D., Eldrige R.
   , Aurias A., Delattre O., Thomas G.
   Nature 363:515-521(1993) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

8. NF2 gene in neurofibromatosis type 2 patients.
   Zucman-Rossi J., Legoix P., Der Sarjussian H., Cheret G., Sor F., Bernardi A., Cazes L., Giraud S., Lenoir G., Thomas G.
   Hum. Mol. Genet. 7:2095-2101(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
9. Novel alternatively spliced isoforms of the neurofibromatosis type 2 tumor suppressor are targeted to the nucleus and cytoplasmic granules.
   Schmucker B., Tang Y., Kressel M.
   Hum. Mol. Genet. 8:1561-1570(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 9 AND 10), SUBCELLULAR LOCATION.
10. Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts.
    Chang L.-S., Akhmametyeva E.M., Wu Y., Zhu L., Welling D.B.
    Genomics 79:63-76(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 8).