Phospho-NFAT5 (S155) Polyclonal Antibody, 100µg, (ATB-P0474)

Description

Background:

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.

Product datasheet:

Overview
Product Description	Phospho-NFAT5 (S155) Polyclonal Antibody, 100µg, (ATB-P0474)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human NFAT5 around the phosphorylation site of S155.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation. Wang Q, et al. Cell Death Dis, 2013 Jun 13. PMID 23764852 Free PMC Article
2. Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5. Caron MM, et al. Bone, 2013 Mar. PMID 23219947
3. Regulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathway. Ranjbar S, et al. PLoS Pathog, 2012. PMID 22496647 Free PMC Article
4. Nuclear import of a lipid-modified transcription factor: mobilization of NFAT5 isoform a by osmotic stress. Eisenhaber B, et al. Cell Cycle, 2011 Nov 15. PMID 22071693 Free PMC Article
5. NF-AT5 is a critical regulator of inflammatory arthritis. Yoon HJ, et al. Arthritis Rheum, 2011 Jul. PMID 21717420 Free PMC Article
6. NFAT5: the NF-AT family of transcription factors expands in a new direction.
   Lopez-Rodriguez C., Aramburu J., Rakeman A.S., Copeland N.G., Gilbert D.J., Thomas S., Disteche C., Jenkins N.A., Rao A.
   Cold Spring Harb. Symp. Quant. Biol. 64:517-526(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Tissue: Brain.
7. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
   Miyakawa H., Woo S.K., Dahl S.C., Handler J.S., Kwon H.M.
   Proc. Natl. Acad. Sci. U.S.A. 96:2538-2542(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
8. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
   Lopez-Rodriguez C., Aramburu J., Rakeman A.S., Rao A.
   Proc. Natl. Acad. Sci. U.S.A. 96:7214-7219(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Tissue: Brain.
9. Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.
   Dalski A., Schwinger E., Zuhlke C.
   Cytogenet. Cell Genet. 93:239-241(2001) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND E).
10. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C). Tissue: Brain.