Phospho-NFATc3 (S165) Polyclonal Antibody, 100µg, (ATB-P0529)

Description

Background:

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Product datasheet:

Overview
Product Description	Phospho-NFATc3 (S165) Polyclonal Antibody, 100µg, (ATB-P0529)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human NFATc3 around the phosphorylation site of S165.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation. Geil WM, et al. FEBS J, 2014 Feb. PMID 24330068 Free PMC Article
2. NFAT4 is required for JC virus infection of glial cells. Manley K, et al. J Virol, 2006 Dec. PMID 17035332 Free PMC Article
3. ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells. Kawano S, et al. Cell Calcium, 2006 Apr. PMID 16445977
4. A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. Amasaki Y, et al. J Biol Chem, 2002 Jul 12. PMID 11997392
5. Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. Imamura R, et al. J Immunol, 1998 Oct 1. PMID 9759864
6. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.
   Hoey T., Sun Y.-L., Williamson K., Xu X.
   Immunity 2:461-472(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5 AND 6). Tissue: Skeletal muscle and T-cell.
7. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.
   Masuda E.S., Naito Y., Tokumitsu H., Campbell D., Saito F., Hannum C., Arai K., Arai N.
   Mol. Cell. Biol. 15:2697-2706(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell.
8. Carboxy-terminal 15 amino acids sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.
   Imamura R., Masuda E.S., Naito Y., Imai S., Fujino T., Takano T., Arai K., Arai N.
   J. Immunol. 161:3455-3463(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Fibroblast and T-cell.
9. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
   Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D.
   Genomics 60:295-308(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 4).
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.