Phospho-NMDAε2 (Y1336) Polyclonal Antibody, 100µg, (ATB-P0809)

Description

Background:

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Product datasheet:

Overview
Product Description	Phospho-NMDAε2 (Y1336) Polyclonal Antibody, 100µg, (ATB-P0809)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human NMDAε2 around the phosphorylation site of Y1336.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. [Association polymorphic variants of GRIN2B gene with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic]. Gareeva AE, et al. Genetika, 2013 Sep. PMID 25486778
2. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Bharadwaj R, et al. Neuron, 2014 Dec 3. PMID 25467983
3. Report on 3 patients with 12p duplication including GRIN2B. Poirsier C, et al. Eur J Med Genet, 2014 Apr. PMID 24503147
4. GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation. Kuswanto CN, et al. Biomed Res Int, 2013. PMID 24490167 Free PMC Article
5. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer’s disease. Andreoli V, et al. J Neural Transm, 2014 May. PMID 24292895
6. Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein.
   Adams S.L., Foldes R.L., Kamboj R.K.
   Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-407. Tissue: Fetal brain.
7. Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
   Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G.
   J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
8. Cloning of GRIN2B human subunit.
   Mandich P., Schito A.M., Pizzuti A., Ratti A.
   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA].
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
10. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.
    Mandich P., Schito A.M., Bellone E., Antonacci R., Finelli P., Rocchi M., Ajmar F.
    Genomics 22:216-218(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-294 AND 661-1089.