Phospho-NMDAζ1 (S897) Polyclonal Antibody, 100 µg, (ATB-P0850)

Description

Background:

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

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References:

1. Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.
   Foldes R.L., Rampersad V., Kamboj R.K.
   Gene 131:293-298(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 11-938 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 300-938 (ISOFORM 2). Tissue: Brain.
2. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
   Karp S.J., Masu M., Eki T., Ozawa K., Nakanishi S.
   J. Biol. Chem. 268:3728-3733(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
3. Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
   Planells-Cases R., Sun W., Ferrer-Montiel A.V., Montal M.
   Proc. Natl. Acad. Sci. U.S.A. 90:5057-5061(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
4. Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
   Zimmer M., Fink T.M., Franke Y., Lichter P., Spiess J.
   Gene 159:219-223(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
5. Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.
   Nash N.R., Heilman C.J., Rees H.D., Levey A.I.
   J. Neurochem. 69:485-493(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7), VARIANTS MET-540 AND SER-682.
6. DNA sequence and analysis of human chromosome 9.
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   Nature 429:369-374(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

7. Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits.
   Foldes R.L., Rampersad V., Kamboj R.K.
   Gene 147:303-304(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 332-922 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 86-259 (ISOFORM 5). Tissue: Cerebellum and Hippocampus.
8. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
   Younkin D.P., Tang C.-M., Hardy M., Reddy U.R., Shi Q.-Y., Pleasure S.J., Lee V.M.-Y., Pleasure D.
   Proc. Natl. Acad. Sci. U.S.A. 90:2174-2178(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-464 (ISOFORMS 1/2/3).
9. Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.
   Tingley W.G., Roche K.W., Thompson A.K., Huganir R.L.
   Nature 364:70-73(1993) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION BY PKC.
10. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors.
    Papadakis M., Hawkins L.M., Stephenson F.A.
    J. Biol. Chem. 279:14703-14712(2004) [PubMed] [Europe PMC] Cited for: INTERCHAIN DISULFIDE BOND.