Phospho-Nur77 (S351) Polyclonal Antibody, 100µg, (ATB-P1019)
$238.00
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Description
Background:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5′-AAAAGGTCA-3′ (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
Product datasheet:
Overview | |
| Product Description | Phospho-Nur77 (S351) Polyclonal Antibody, 100µg, (ATB-P1019) |
| Species Reactivities | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human Nur77 around the phosphorylation site of S351. |
Properties | |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instructions | -20°C/1 year |
| Clonality | Polyclonal |
References:
- NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas. Deutsch AJ, et al. Blood, 2014 Apr 10. PMID 24553175
- The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Lee SO, et al. Mol Cancer Res, 2014 Apr. PMID 24515801
- Nur77 inhibits androgen-induced bladder cancer growth. Wu J, et al. Cancer Invest, 2013 Dec. PMID 24299210
- NR4A orphan nuclear receptors in glucose homeostasis: a minireview. Close AF, et al. Diabetes Metab, 2013 Dec. PMID 24075454
- TR3 modulates platinum resistance in ovarian cancer. Wilson AJ, et al. Cancer Res, 2013 Aug 1. PMID 23720056 Free PMC Article
- A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily.
Nakai A., Kartha S., Sakurai A., Toback F.G., Degroot L.J.
Mol. Endocrinol. 4:1438-1443(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal skeletal muscle. - Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.
Chang C., Kokontis J., Liao S., Chang Y.
J. Steroid Biochem. 34:391-395(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). - Identification of an isoform of human TR3 (NGFI-B, Nur77).
Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Skeletal muscle. - Comprehensive DNA-binding analysis of human hormone nuclear receptors by fluorescence correlation spectroscopy based on cell-free system.
Kobayashi T., Kodani Y., Sawasaki T., Endo Y.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). - Isolation of cDNA coding for multiple human nuclear receptor clones.
Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
| size | chest(in.) | waist(in.) | hips(in.) |
|---|---|---|---|
| XS | 34-36 | 27-29 | 34.5-36.5 |
| S | 36-38 | 29-31 | 36.5-38.5 |
| M | 38-40 | 31-33 | 38.5-40.5 |
| L | 40-42 | 33-36 | 40.5-43.5 |
| XL | 42-45 | 36-40 | 43.5-47.5 |
| XXL | 45-48 | 40-44 | 47.5-51.5 |
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