Phospho-OSR1 (T185) Polyclonal Antibody, 100µg, (ATB-P0793)

Description

Background:

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

Product datasheet:

Overview
Product Description	Phospho-OSR1 (T185) Polyclonal Antibody, 100µg, (ATB-P0793)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human OSR1 around the phosphorylation site of T185.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573 Free PMC Article
2. Structure of the OSR1 kinase, a hypertension drug target. Villa F, et al. Proteins, 2008 Dec. PMID 18831043
3. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Tamari M, et al. J Hum Genet, 1999. PMID 10083736
4. Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers. Ponce-Coria J, et al. Am J Physiol Cell Physiol, 2012 Dec 1. PMID 23034389 Free PMC Article
5. STK39 is an independent risk factor for male hypertension in Han Chinese. Chen LY, et al. Int J Cardiol, 2012 Jan 26. PMID 20889219
6. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.
   Tamari M., Daigo Y., Nakamura Y.
   J. Hum. Genet. 44:116-120(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-304. Tissue: Skeletal muscleImported

7. <p>Manually validated information which has been imported from another database.</p>
10. <p><a href=”/manual/evidences#ECO:0000312″>More…</a></p> Manual assertion inferred from database entriesⁱ
    EMBL:BAA75674.1