Phospho-p130 Cas (Y165) Polyclonal Antibody, 100µg, (ATB-P0697)

Description

Background:

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Product datasheet:

Overview
Product Description	Phospho-p130 Cas (Y165) Polyclonal Antibody, 100µg, (ATB-P0697)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human p130 Cas around the phosphorylation site of Y165.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi’s sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cells. Bandyopadhyay C, et al. J Virol, 2014 Dec. PMID 25253349
2. Increased BCAR1 predicts poor outcomes of non-small cell lung cancer in multiple-center patients. Deng B, et al. Ann Surg Oncol, 2013 Dec. PMID 23904007 Free PMC Article
3. Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex. Hempel N, et al. Mol Cancer Res, 2013 Mar. PMID 23345605 Free PMC Article
4. p130Cas acts as survival factor during PMA-induced apoptosis in HL-60 promyelocytic leukemia cells. Kumbrink J, et al. Int J Biochem Cell Biol, 2013 Mar. PMID 23287717 Free PMC Article
5. p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. Camacho Leal Mdel P, et al. PLoS One, 2012. PMID 23239970 Free PMC Article
6. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells.
   Brinkman A., van der Flier S., Kok E.M., Dorssers L.C.J.
   J. Natl. Cancer Inst. 92:112-120(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-76. Tissue: Mammary cancer.
7. Interaction between human Crk-associated substrate (p130Cas) and nephrocystin.
   Otto E., Birnbaum S., Verbeek M., Hildebrandt F.
   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-76. Tissue: Testis.
8. The effects of growth factors on tyrosine phosphorylation of p130Cas in corneal epithelial cell.
   Imoto Y., Ohguro N., Yoshida A., Tsujikawa M., Inoue Y., Tano Y.
   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-76. Tissue: Cornea.
9. Lin L., Li H., Zhou G., Shen C., Ke R., Zhong G., Yang S.
   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
10. Complete sequencing and characterization of 21,243 full-length human cDNAs.
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4; 5; 6; 7 AND 8), VARIANT SER-76. Tissue: Amygdala, Caudate nucleus, Cerebellum, Hippocampus, Teratocarcinoma and Testis.