Phospho-p47-phox (S328) Polyclonal Antibody, 100µg, (ATB-P1018)
$238.00
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Description
Background:
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Product datasheet:
Overview | |
| Product Description | Phospho-p47-phox (S328) Polyclonal Antibody, 100µg, (ATB-P1018) |
| Species Reactivities | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human p47-phox around the phosphorylation site of S328. |
Properties | |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instructions | -20°C/1 year |
| Clonality | Polyclonal |
References:
- Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1. Kozel BA, et al. Hypertension, 2014 Jan. PMID 24126171 Free PMC Article
- Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease. Hayrapetyan A, et al. Biochim Biophys Acta, 2013 Oct. PMID 23688784
- Defining p47-phox deficient Chronic Granulomatous Disease in a Malay family. Gill HK, et al. Asian Pac J Allergy Immunol, 2012 Dec. PMID 23393912
- Diabetes, renal and cardiovascular disease in p47 phox-/- chronic granulomatous disease. Leiding JW, et al. J Clin Immunol, 2013 May. PMID 23386289 Free PMC Article
- Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR. Stampoulis P, et al. J Biol Chem, 2012 May 18. PMID 22493288 Free PMC Article
- Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.
Volpp B.D., Nauseef W.M., Clark R.A.
Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Erratum
Volpp B.D., Nauseef W.M., Clark R.A.
Proc. Natl. Acad. Sci. U.S.A. 86:9563-9563(1989)Cited for: SEQUENCE REVISION. - Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
Lomax K.J., Leto T.L., Nunoi H., Gallin J.I., Malech H.L.
Science 245:409-412(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS SER-99 AND ASP-166. - Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid.
Rodaway A.R.F., Teahan C.G., Casimir C.M., Segal A.W., Bentley D.L.
Mol. Cell. Biol. 10:5388-5396(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-99 AND ASP-166. - A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease.
Gorlach A., Lee P.L., Roesler J., Hopkins P.J., Christensen B., Green E.D., Chanock S.J., Curnutte J.T.
J. Clin. Invest. 100:1907-1918(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-99.
| size | chest(in.) | waist(in.) | hips(in.) |
|---|---|---|---|
| XS | 34-36 | 27-29 | 34.5-36.5 |
| S | 36-38 | 29-31 | 36.5-38.5 |
| M | 38-40 | 31-33 | 38.5-40.5 |
| L | 40-42 | 33-36 | 40.5-43.5 |
| XL | 42-45 | 36-40 | 43.5-47.5 |
| XXL | 45-48 | 40-44 | 47.5-51.5 |
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