Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody, 100µg, (ATB-P0668)

Description

Background:

This gene encodes one of four mammalian counterparts to the fruit fly ‘dunce’ gene. The encoded protein has 3′,5′-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Product datasheet:

Overview
Product Description	Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody, 100µg, (ATB-P0668)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human PDE4B/C/D around the phosphorylation site of S133/119/190.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke. Yan Y, et al. J Neurol Sci, 2014 Mar 15. PMID 24365247
2. Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients. Heyer EJ, et al. Neurosurgery, 2013 Nov. PMID 23863764 Free PMC Article
3. PDE4D gene polymorphisms and coronary heart disease: a case-control study in a north Indian population. Sinha E, et al. J Clin Lab Anal, 2013 Jul. PMID 23852788
4. Genetic polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis. Liu X, et al. PLoS One, 2013. PMID 23799094 Free PMC Article
5. [Association of rs966221 phosphodiesterase 4D gene’s polymorphism with risk of myocardial infarction]. Pleskach HV, et al. Lik Sprava, 2012 Dec. PMID 23786009
6. The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
   Obernolte R., Bhakta S., Alvarez R., Bach C., Mulkins M., Jarnagin K., Shelton E.R.
   Gene 129:239-247(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B2).
7. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
   Bolger G., Michaeli T., Martins T., St John T., Steiner B., Rodgers L., Riggs M., Wigler M., Ferguson K.
   Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE4B1 AND PDE4B2). Tissue: Brain.
8. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
   Huston E., Lumb S., Russell A., Catterall C., Ross A.H., Steele M.R., Bolger G.B., Perry M.J., Owens R.J., Houslay M.D.
   Biochem. J. 328:549-558(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B3).
9. A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.
   McLaughlin M.M., Cieslinski L.B., Burman M., Torphy T.J., Livi G.P.
   J. Biol. Chem. 268:6470-6476(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B2). Tissue: Brain.
10. PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).
    Cheung Y.F., Kan Z., Garrett-Engele P., Gall I., Murdoch H., Baillie G.S., Camargo L.M., Johnson J.M., Houslay M.D., Castle J.C.
    J. Pharmacol. Exp. Ther. 322:600-609(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4B5).