Phospho-PLC γ2 (Y1217) Polyclonal Antibody, 100µg, (ATB-P0888)

Description

Background:

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Product datasheet:

Overview
Product Description	Phospho-PLC γ2 (Y1217) Polyclonal Antibody, 100µg, (ATB-P0888)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human PLC γ2 around the phosphorylation site of Y1217.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Zhou Q, et al. Am J Hum Genet, 2012 Oct 5. PMID 23000145 Free PMC Article
2. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. Ombrello MJ, et al. N Engl J Med, 2012 Jan 26. PMID 22236196 Free PMC Article
3. Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2. Everett KL, et al. Mol Cell Biol, 2011 Mar. PMID 21245382 Free PMC Article
4. Molecular profiling of isolated histological components of wilms tumor implicates a common role for the Wnt signaling pathway in kidney and tumor development. Maschietto M, et al. Oncology, 2008. PMID 18784435
5. Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. Piechulek T, et al. J Biol Chem, 2005 Nov 25. PMID 16172125
6. Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
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   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
8. NovelFam3000 — uncharacterized human protein domains conserved across model organisms.
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   BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
9. The sequence and analysis of duplication-rich human chromosome 16.
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   Nature 432:988-994(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].