Phospho-PR (S294) Polyclonal Antibody, 100µg, (ATB-P0531)

Description

Background:

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.

Product datasheet:

Overview
Product Description	Phospho-PR (S294) Polyclonal Antibody, 100µg, (ATB-P0531)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human PR around the phosphorylation site of S294.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. Tangen IL, et al. Eur J Cancer, 2014 Nov. PMID 25281525
2. Association of the progesterone receptor gene polymorphism (PROGINS) with endometriosis: a meta-analysis. Pabalan N, et al. Arch Gynecol Obstet, 2014 Nov. PMID 24943061
3. Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord. Gargiulo-Monachelli GM, et al. Eur J Neurol, 2014 Feb. PMID 24894997
4. Prostate stromal cells express the progesterone receptor to control cancer cell mobility. Yu Y, et al. PLoS One, 2014. PMID 24664419 Free PMC Article
5. Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential. Feng Q, et al. J Clin Endocrinol Metab, 2014 Mar. PMID 24423317
6. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
   Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H., Chambon P.
   EMBO J. 9:1603-1614(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANT THR-344.
7. Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA.
   Misrahi M., Atger M., D’Auriol L., Loosfelt H., Meriel C., Fridlansky F., Guiochon-Mantel A., Galibert F., Milgrom E.
   Biochem. Biophys. Res. Commun. 143:740-748(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-660.
8. Kieback D.G., Agoulnik I.U., Tong X.-W.
   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-660.
9. Progesterone Receptor, alternative splicing variant, mRNA.
   Hisatomi H., Wakita K., Kohno N., Nagao K., Hirata H., Hikiji K.
   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Mammary tumor.
10. The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor.
    Chen C., Opazo J.C., Erez O., Uddin M., Santolaya-Forgas J., Goodman M., Grossman L.I., Romero R., Wildman D.E.
    Mol. Phylogenet. Evol. 47:637-649(2008) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].