Phospho-Smad1 (S187) Polyclonal Antibody, 100µg, (ATB-P0744)

Description

Background:

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.

Product datasheet:

Overview
Product Description	Phospho-Smad1 (S187) Polyclonal Antibody, 100µg, (ATB-P0744)
Image
Species Reactivities	Human,Mouse,Monkey
Immunogen	Synthesized peptide derived from human Smad1 around the phosphorylation site of S187.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

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2. [BMP4-Smad1 signaling pathway in pathogenesis of diabetic nephropathy]. Abe H, et al. Nihon Jinzo Gakkai Shi, 2011. PMID 22073863
3. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Cook BD, et al. Blood, 2011 Jun 16. PMID 21515822 Free PMC Article
4. Modification of Smad1 linker modulates BMP-mediated osteogenesis of adult human MSC. Skarżyńska J, et al. Connect Tissue Res, 2011 Oct. PMID 21405981
5. Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker. Abe H, et al. Histol Histopathol, 2011 Apr. PMID 21360446
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