Phospho-Stat2 (Y690) Polyclonal Antibody, 100 µg, (ATB-P0612)

Description

Background:

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Product datasheet:

References:

1. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
   Fu X.-Y., Schindler C., Improta T., Aebersold R., Darnell J.E. Jr.
   Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
2. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.
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   Nucleic Acids Res. 23:459-463(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
3. NIEHS SNPs program
   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-448; VAL-464; ILE-594 AND HIS-826.
4. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Tongue.

5. The finished DNA sequence of human chromosome 12.
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   Nature 440:346-351(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
7. A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).
   Fu X.Y.
   Cell 70:323-335(1992) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION IN RESPONSE TO IFN-ALPHA.
8. Role of STAT2 in the alpha interferon signaling pathway.
   Leung S., Qureshi S.A., Kerr I.M., Darnell J.E. Jr., Stark G.R.
   Mol. Cell. Biol. 15:1312-1317(1995) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT TYR-690, MUTAGENESIS OF TYR-690.
9. Identification of alternative splicing form of Stat2.
   Sugiyama T., Nishio Y., Kishimoto T., Akira S.
   FEBS Lett. 381:191-194(1996) [PubMed] [Europe PMC] Cited for: POTENTIAL ALTERNATIVE SPLICING.
10. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
    Bluyssen H.A., Levy D.E.
    J. Biol. Chem. 272:4600-4605(1997) [PubMed] [Europe PMC] Cited for: FUNCTION, SUBUNIT.