Phospho-Syndecan-4 (S179) Polyclonal Antibody, 100µg, (ATB-P1150)

Description

Background:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Cell surface proteoglycan that bears heparan sulfate.

Product datasheet:

References:

1. [Changes and clinical significance of serum level of syndecan-4 protein in patients with chronic congestive heart failure]. Ma X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2013 Aug. PMID 23948417
2. Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours. Labropoulou VT, et al. Biomed Res Int, 2013. PMID 23844358 Free PMC Article
3. Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases. Tan X, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Apr 1. PMID 22268118
4. Lysophosphatidylcholine-mediated functional inactivation of syndecan-4 results in decreased adhesion and motility of dendritic cells. Bühligen J, et al. J Cell Physiol, 2010 Nov. PMID 20607801
5. Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner. Keller-Pinter A, et al. Cell Mol Life Sci, 2010 Jun. PMID 20229236
6. Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.
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   J. Cell Biol. 118:961-969(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LEU-12. Tissue: Lung fibroblast.
7. Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.
   Kojima T., Inazawa J., Takamatsu J., Rosenberg R.D., Saito H.
   Biochem. Biophys. Res. Commun. 190:814-822(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
8. Structural organization and promoter activity of the human ryudocan gene.
   Takagi A., Kojima T., Tsuzuki S., Katsumi A., Yamazaki T., Sugiura I., Hamaguchi M., Saito H.
   J. Biochem. 119:979-984(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thalamus.

10. Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).